Microsofts x64 editions of Windows XP Professional and Windows Server 2003 enable organizations to get the most out of their AMD64- and EM64T-based hardware. However, while processors based on these architectures natively run most existing 32-bit applications without a hitch, sites contemplating the upgrade need to watch out for these potential 32/64-bit trouble spots:
32-bit hardware drivers and kernel-mode applications must be ported to run on Windows x64. AMD has assembled a list of compatible drivers and applications at www.amd.com/us-en/Processors/DevelopWithAMD/0,,30_ 2252_869_875%5e10454,00.html?redir=IEGFC07.
Windows x64 wont run 16-bit code. Microsoft provides some workaround information for this issue at support.microsoft.com/?kbid=896458&SD=tech.
Windows x64 editions drop support for a number of legacy protocols and subsystems, including MS-DOS, OS/2 and POSIX subsystems and the IPX/SPX, AppleTalk, Services for Macintosh, DLC LAN, NetBEUI, IrDA and OSPF protocols.
Source: eWEEK Reporting
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