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    Home Latest News

      Virtual Cells Could Speed Drug Discovery

      By
      M.L. Baker
      -
      June 6, 2005
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        Using programs developed to simulate stock markets and warfare, researchers at the University of Chicago have developed software to simulate a more complicated process: the workings of an individual bacterial cell. The tool, called AgentCell, could speed drug discovery and help fight cancer and bioterrorism.

        Researchers could get results in less time using virtual cells rather than real ones. They also could avoid working with dangerous pathogens.

        And so far, digital experiments predicting how bacteria will swim in response to environmental cues have produced results similar to those from experiments using real bacteria, for both single cells and bacteria populations, according to a paper published this month in the journal Bioinformatics by Philippe Cluzel, Thierry Emonet and others at the University of Chicagos Institute for Biophysical Dynamics.

        The “digital cells” are virtual versions of the species E. coli, the microbial equivalent of a laboratory rat. These digital bacteria can sense likely food molecules in a virtual environment. They can transmit biochemical signals to their flagella, whiplike structures that bacteria use for locomotion, correctly mimicking how the bacteria will move.

        Using the digital cells, Emonet found that levels of a particular protein could make a bacterium more or less likely to respond to environmental cues. Follow-up experiments on real bacteria showed the same thing.

        /zimages/2/28571.gifClick here to read about practical applications for bioinformatics.

        The advantage of this computer simulation is that it can simultaneously model the activity of the molecular machinery inside a cell, the bacterial cell itself and a group of several bacteria. Though other simulations can model these individually, the Chicago researchers say they know of no other software that can model all three scales at once.

        “With AgentCell, we can simulate the behavior of entire populations of cells as they sense their environment, respond to stimuli and move in a three-dimensional world,” Emonet said.

        /zimages/2/28571.gifRead the full story on CIOInsight.com: Virtual Cells Could Speed Drug Discovery

        M.L. Baker
        Monya Baker is co-editor of CIOInsight.com's Health Care Center. She has written for publications including the journal Nature Biotechnology, the Acumen Journal of Sciences and the American Medical Writers Association, among others, and has worked as a consultant with biotechnology companies. A former high school science teacher, Baker holds a bachelor's degree in biology from Carleton College and a master's of education from Harvard.

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